Their interactions have not been studied. Manufacturers use different processes to produce their insulins, and different preservatives. Insulins made by different manufacturers should not be mixed, e.g., Humulin-R® (Eli Lilly) should not be mixed with Novolin-N® (Novo-Nordisk).
Regular insulin is taken 30 minutes before eating and also may be mixed with NPH. Humalog®, Novolog®, and Apidra® may be taken up to 15 minutes before eating and, if using vials, may be mixed with NPH. Insulin can be injected in the abdomen, legs, back of arms, or buttocks. Insulin directly lowers glucose levels by increasing uptake into muscle and fatty tissue, and reducing release of glucose from the liver. Insulin helps control blood sugar levels in people whose bodies do not produce enough insulin. * Onset how long it takes before the insulins begin to work peak the time during which the insulins are at their maximum effectiveness in lowering blood glucose duration is how long the insulins continue to work before their effects wear off How it works: NovoLog® mix 70/30 (70% insulin aspart protamine and 30% insulin aspart). Humalog® mix 50/50 (50% insulin lispro protamine and 50% insulin lispro). Humalog® mix 75/25 (75% NPL and 25% insulin lispro) Rapid-acting insulins (bolus insulin) are usually taken at the start of a meal. Medication name: Insulin degludec U-100/U-200 (Tresiba®). Medication name: Insulin glargine U-300 (Toujeo®). Medication name: Insulin U-100 (Lantus®, Basaglar®). Medication name: Insulin detemir (Levemir®). Medication name: NPH insulin (Novolin N, Humulin N). Medication name: Regular insulin (Novolin R, Humulin R). 
Medication name: Insulin lispro U-100/U-200 (Humalog®).Medication name: Insulin aspart (Novolog®).
Medication name: Insulin glulisine (Apidra®).
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